Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function.

However, the precise mechanism(s) that facilitate and regulate this process for vision is not fully understood, and elucidation will be highly significant given the role vitamin A metabolites (retinoids) play in retinal health and disease states [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 17 , 19 ].

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However, while we did observe a modest shortening of the photoreceptor outer segments (OS) in the retinas of young Rbpr2 −/− mice fed a VAS diet, this did not reach statistical significance ( Figure S2B,C ).

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