Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFNγ-dependent mortality in STING gain-of-function mice.

When T cells isolated from the VM lung were treated with brefeldin A, both CD4 + and CD8 + αβ extravascular (EV) T cells showed a higher frequency of IFNγ + cells than WT control cells, although CD8 T cell IFNγ production did not reach statistical significance of P < 0.05 ( P = 0.1470) ( Fig. 3 A and B ).

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