Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions.

Although densitometric analysis of the Western blot images did not show statistically significant differences in the levels of GPIIb, GPIIIa, and PF4 between plasma and serum ( P = 0.19, 0.18, and 0.057, respectively; Student t -test) owing to large variances between individuals ( Fig 5D ), a clear trend of a selective increase in platelet-associated proteins in serum is in good agreement with the results observed in mouse blood experiments ( Fig 4 ).

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