ABO blood group and link to COVID-19: A comprehensive review of the reported associations and their possible underlying mechanisms.

Among the studies summarized here ( Table 2 ), the majority did not reach statistical significance, and we were unable to identify any trend in the outcomes according to the size of the enrolled groups.

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However, it is possible to observe a trend towards significance when the enrolled group consisted of critically ill COVID-19 patients – like those requiring ICU admission [ 86 ] or blood transfusion [ 18 ] and those presenting severe hypoxia [ 17 ] - or patients with cardiovascular co-morbidities [ 77 , 87 ].

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