Ongoing Positive Selection Drives the Evolution of SARS-CoV-2 Genomes.

We profiled those within-cluster mutations according to their frequency dynamics during a period of 30 sequential sampling times, and 11 mutations demonstrating a significant trend of increased frequency over sampling times (simultaneously tested by M&K, C&S, and LinRegress tests; P < 0.005) independently within at least two clusters were identified ( Figure S2 ).

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When under purifying selection, r j values are expected to decrease with j ; while under positive selection, an increasing trend of r j values is expected.

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