Bone Volumetric Density, Microarchitecture, and Estimated Bone Strength in Tumor-Induced Rickets/Osteomalacia <i>Versus</i> X-linked Hypophosphatemia in Chinese Adolescents.

At the distal tibia, although the total bone area was similar (22.2%, p = 0.195) and the difference of the trabecular bone area only reached marginal significance (36.6%, p = 0.075) between the TIR/O patients and the healthy controls, the TIR/O patients still had 40.5% significantly smaller cortical bone area than the healthy controls ( p = 0.002).

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Comparing the TIR/O Group to the XLH Group At the distal radius, compared with the XLH group, the TIR/O group showed significant or marginally significant differences only in a few trabecular parameters ( Table 2 and Supplementary Figure S1A ), such as lower trabecular number (-28.6%, p = 0.076), greater trabecular inhomogeneity (79.0%, p = 0.049), and larger trabecular separation (51.2%, p = 0.074).

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Unlike vBMDs, differences of aBMDs between groups did not reach statistical significance, which might be caused by the huge variations within groups, further indicating that aBMD is not an ideal parameter to evaluate osteomalacia.

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