A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts.

In the secondary, combined meta-analysis, a total of 57 SNPs were associated with BDR at p<5×10 −6 ( supplementary table S2 ), 21 SNPs after linkage disequilibrium clumping ( table 2 ) and one SNP (rs4782614) associated with BDR as defined by per cent change in FEV 1 nearing significance (p=7.5×10 −8 ).

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Although SNPs with nominally significant (p<5×10 −6 ) associations with BDR are highlighted above, none reached conventional genome-wide significance, despite combined samples sizes of 10 623 EA and 3597 AA participants.

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