Increased Expression of <i>LASI</i> lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia.

RNA-interference based silencing works primarily in the cytosolic region and even with only 37.5% suppression of LASI lncRNA levels, we observed a highly significant reduction in CSE-induced MUC5AC, ICAM-1, and IL-6 expression.

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Among inflammatory factors, mRNA levels of IL-6 were upregulated in mild COPD samples only ( Supplementary Figure S1B ) and ICAM-1 mRNAs showed a trend towards upregulated expression in mild and severe COPD tissue samples, as compared to no-COPD controls ( Supplementary Figure S1C ).

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