Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.

Slug expression was also reduced in the Bcar1 SM22KO mutants but this did not reach statistical significance, possibly due to low Slug expression and the mixed cell population in the tissue lysates analysed. 3.7 Bcar1 deletion in NCC causes defective OFT septation and abnormal AS dilatation To identify more precisely the role of Bcar1 in heart development, we generated conditional Bcar1 knockouts using the Mef2c-Cre ( Bcar1 MEF2CKO ) and Pax3-Cre ( Bcar1 PAX3KO ) transgenic mouse lines, which generate genetic deletions targeted, respectively, to cells that give rise to the second heart field, and to NCC.

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