Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective cohort study (COVI-GAPP).

HRV ratio As with SDNN, multilevel analysis revealed a marginally significant decrease in HRV ratio during the incubation ( β i n c u b a t i o n = −0.01, SE=0.01; p=0.0361) and presymptomatic periods ( β p r e - s y m p t o m a t i c = −0.02, SE = −0.01; p=0.0165) compared with baseline ( β i n t e r c e p t = 0.50, SE=0.02; p<0.0001).

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To ensure a family-wise alpha level less than or equal to 0.05, we implemented Bonferroni correction for the seven analysed parameters (corrected alpha level of p=0.007) and adjusted the definition of marginal significance accordingly (ie, 0.007≤p ≤ 0.05).

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