Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer's disease cognition.

Alzheimers Res Ther · 2022 · PMC9241285 · PMID 35768831

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showed a trendno p-value reported

Olanzapine showed a trend toward greater benefit for subjects of older age, although the result was not statistically significant (Fig. 5 d).

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