EGR2 Deletion Suppresses Anti-DsDNA Autoantibody and IL-17 Production in Autoimmune-Prone B6/lpr Mice: A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice.

Front Immunol · 2022 · PMC9241489 · PMID 35784356

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The intracellular cytokine analysis showed a trend of increase of IL-17 expression in gated CD4 + , but not CD8 + T cells of EGR2 -/- B6 mice ( Figures 9E, F ) We then activated splenocytes with Th17-inducing stimuli to confirm the differential role of EGR2 in the regulation of Th17 effector responses in B6/lpr versus B6 mice.

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