Peptidoglycan-Like Components in Z-100, Extracted from <i>Mycobacterium tuberculosis</i> Strain Aoyama B, Increase IL-12p40 via NOD2.

J Immunol Res · 2022 · PMC9242757 · PMID 35785036

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showed a trendno p-value reported

Further, subcutaneous administration of Z-100 to mice significantly elevated expression of IL-12p40 and IL-1 β and showed a trend towards increasing TNF- α in the skin.

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an increasing trendno p-value reported

Further, TNF- α gene expression also showed an increasing trend, although the change was not significant ( Figure 6(c) ).

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