Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions.

Thus, sphingolipid metabolism was identified as the most significantly different pathway for the HILIC pos/neg analysis (method #2), but did not reach statistical significance for the RPLC pos/HILIC pos analysis (method #1) (Fig. 7c, d ).

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