Understanding and managing the suppression of spermatogenesis caused by testosterone replacement therapy (TRT) and anabolic-androgenic steroids (AAS).

However, another randomized placebo-controlled trial investigating a higher dose of finasteride (5 mg) and dutasteride (0.5 mg) found there was a reduction in sperm concentration and motility at 6 and 12 months with the 5ARIs (although the reduction at 12 months did not reach statistical significance). 32 It is unclear whether these are the direct effects of a reduced intratesticular DHT or whether the elevation in serum testosterone with 5ARIs causes a suppressive effect on spermatogenesis. 32 The authors also reported that restoration of spermatogenesis was seen when patients were rev

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