Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea.

Haematologica · 2022 · PMC9244815 · PMID 34706496

Europe PMC DOI

hedged sentences

0.2100

closest p · 4.2× alpha

0.2100

boldest claim

The sentences

a slight trendP =0.21not close (p > 0.1)

In contrast, among patients carrying the HBG2- polymorphism rs7482144, there was a slight trend towards a higher total hemoglobin in those who suffered from severe disease (10.8±1.6 g/dL vs . 10.0±1.1 g/dL, P =0.21).

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showed a trendno p-value reported

Without having any detectable effect on HbF levels, BCL11A rs7606173 showed a trend towards higher LDH and more frequent hospitalizations and ACS.

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