Retromer dysfunction in amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A · 2022 · PMC9245686 · PMID 35749364

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0.0200

closest p · 0.4× alpha

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The sentences

nominally significantP = 0.02actually significant

Although this difference in proportions was nominally significant (uncorrected P = 0.02), we did not see this effect in the equivalent analysis in the WGS cohort, where the proportion of HRCGS genes with more variants in ALS patients was indistinguishable from non-HRCGS genes (54% or 30 of 56 vs. 52% or 4,151 of 8,017, P = 0.089).

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