Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.

Proc Natl Acad Sci U S A · 2022 · PMC9245707 · PMID 35737830

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did not reach statistical significanceno p-value reported

TET1, TET2, and TET3 mRNA levels also tended to increase in patients with obesity or diabetes, compared to lean individuals, although this difference did not reach statistical significance, possibly due to negative feedback on TET expression in humans under obese or diabetic conditions ( SI Appendix , Fig.

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