nominally significantp = 3.4 × 10 −4
In a large meta-analysis, this SERPINA1 variant had only a nominally significant association with waist-to-hip ratio (beta = −0.03, p = 3.4 × 10 −4 )—the closest anthropometric correlate of VAT/GFAT ratio—highlighting the utility of image-derived phenotypes for this discovery 12 .