Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure.

Front Cardiovasc Med · 2022 · PMC9247256 · PMID 35783854

Europe PMC DOI

hedged sentences

0.0034

closest p · 0.1× alpha

0.3300

boldest claim

The sentences

highly significantp = 0.0034actually significant

PKA activity assay from LV lysates showed a highly significant reduction (62%, p = 0.0034) in the IHD LVs compared with that of controls, while PKG activity remained stable ( Figure 3F ).

also in 132,142 other papers

did not reach statistical significancep = 0.33not close (p > 0.1)

The PKG protein level was remarkably elevated in the IHD group (65%, p = 0.003), while the phosphorylation of its downstream target, Ser239 in vasodilator-stimulated phosphoprotein (VASP), was also enhanced (19%), although the increase did not reach statistical significance ( p = 0.33, Figure 3B ).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.