Vγ2 x PD-L1, a Bispecific Antibody Targeting Both the Vγ2 TCR and PD-L1, Improves the Anti-Tumor Response of Vγ2Vδ2 T Cell.

We further observed that the Vγ2 x PD-L1-induced Vγ2Vδ2 T cells’ cytotoxicity (killing EC 50 ) towards tumor cells was correlated significantly with these tumor cells’ PD-L1 expression scores, while the release IFNγ EC 50 showed a negative trend with the PD-L1 expression scores ( Figure 6C ).

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