Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5.

Front Pharmacol · 2022 · PMC9247443 · PMID 35784713

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a clear trendno p-value reported

It is interesting that the phosphorylated ligands demonstrated a clear trend to be the least selective and most potent but display more partial agonism for S1P 5 , and that the more recent novel small molecule compounds display more refined selectivity for S1P 1 and S1P 5 .

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