There was a trend toward lower transmission with prenatal treatment with pyrimethamine + sulfadiazine compared to spiramycin (18.5% vs 30%, respectively, p = 0.147, Odds ratio = 0.53; 95% CI 0.23–1), but it did not reach statistical significance, possibly for lack of statistical power due to a lower than expected sample size when the study was discontinued ( Mandelbrot et al., 2018 ).
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