Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity.

Concurrent with the weight loss and gene expression changes, the adipocyte perimeter showed a trend towards a more reduced size in the high-nutrient-quality ER diet group when compared to the low-nutrient-quality ER diet group (group comparison, P = 0.034; post hoc analyses: high-nutrient-quality ER diet group compared with control group, P = 0.010; high- compared with low-nutrient-quality ER diet groups, P = 0.098), as assessed in a subset (low-nutrient-quality ER diet group, n = 22; high-nutrient-quality ER diet group, n = 9; control group, n = 10) of the study population.

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