The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency.

The production and/or secretion of IFN-γ and TNF-α was significantly increased or exhibited a positive trend in knockdown cultures.

also in 11,005 other papers

Whereas knockdown significantly increased granzyme B and perforin expression, overexpression resulted in a reduction or a negative trend in the expression of these effector molecules ( Figure 5C ).

also in 4,201 other papers