REL-1017 (esmethadone; D-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats.

Sci Rep · 2022 · PMC9259683 · PMID 35794162

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

5 H) measures over the time interval of 31–39 days for morphine-treated rats (blue dot) showed a trend of increase compared to the AUC of vehicle (black dot, p = 0.058).

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