An Integrated Analysis of Clinical, Genomic, and Imaging Features Reveals Predictors of Neurocognitive Outcomes in a Longitudinal Cohort of Pediatric Cancer Survivors, Enriched with CNS Tumors (Rad ART Pro).

In the nested case-control candidate gene analyses comparing proportion of APOE ε4 carrier and non-carriers within the highest and lowest performers in neurocognitive testing , APOE ε4 carriers had the greatest odds of being among the poorest performers across all neurocognitive domains at all time points tested (Odds ratio [OR] 2.85, P =0.002), BDNF carriers showed the lowest odds, (OR 0.52, P =0.001), and COMT did not reach statistical significance ( Table 4 ).

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