Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8⁺ T Cells in Unexposed Individuals.

Although the results did not reach statistical significance, probably due to individual variability and low sample number, IFNγ production appeared to be lower in the elderly, which is consistent with a recent report showing no significant upregulation of IFNγ production in the elderly after the first dose of SARS-CoV-2 vaccine BNT162b2 ( Collier et al., 2021 ).

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