Age and CMV-Infection Jointly Affect the EBV-Specific CD8⁺ T-Cell Repertoire.

The normalized richness of the antigen-specific T-cell repertoires against both CMV A2−NLV and EBV A2−GLC showed a negative trend with age ( p = ns, r = 0.1786 and p = 0.0645, r = −0.5105, respectively), although the decrease with age observed for the CMV A2−NLV -specific samples was largely based on the datapoint of one young adult ( Figure 5A ).

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The percentage of CD57 + T cells showed a positive trend with age for CMV A2−NLV -specific T cells ( p = 0.0645, r = 0.2689), while it was low across all ages for EBV A2−GLC - specific T cells ( Figure 2D ).

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