Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication.

These analyses showed a clear trend toward increased expression after 8 and 12 h at warmer temperature (Figure 4D ), resembling the kinetics of accumulation of the respective mRNAs (Figure 4A ).

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This notion is further supported by GO term analysis of genes that increase between 37 and 38°C, showing a strong and highly significant enrichment of processes such as ‘response to biotic stimuli’, ‘response to virus’ or ‘response to interferon’ among other innate immunity-related GO terms (Figure 1D ).

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