Patients deriving long-term benefit from immune checkpoint inhibitors demonstrate conserved patterns of site-specific mutations.

3 F,G), the relationship between total mutational burden and survival did not reach statistical significance in this cohort of colorectal cancer patients (Fig. 3 H), though it remained a significant prognostic factor in the melanoma cohort (F i g. 3 I).

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Patients with a mutation to one or more of these genes had a highly significant improvement in overall survival when compared to the non-mutated group (Fig. 2 D), as well as an increase in the number of total mutations (Fig. 2 E).

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