Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children.

As expected, interferon-stimulated genes (ISGs) were prominent among the genes highly significant in both age cohorts (Supplementary Fig. 1a ).

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Samples in the SARS-CoV-2 group in both age cohorts spanned several orders of magnitude of viral load, and while viral load trended higher in the children, this did not reach statistical significance (Fig. 1c ).

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