Shuangxinfang Prevents S100A9-Induced Macrophage/Microglial Inflammation to Improve Cardiac Function and Depression-Like Behavior in Rats After Acute Myocardial Infarction.

Front Pharmacol · 2022 · PMC9263923 · PMID 35814253

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a clear trendno p-value reported

On the contrary, the results showed that relative to the AMI group, the hippocampal S100A9 ( p < 0.01), IL-1β ( p < 0.05), and TNF-α ( p < 0.001) levels were obviously downregulated after ABR-215757 intervention, while the myocardial S100A9 ( p < 0.05) and TNF-α ( p < 0.001) levels also showed a clear trend of descending.

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an increasing trendno p-value reported

Similar to the above results, in AMI-induced depressive rats, the level of S100A9 showed an increasing trend in the myocardium and the hippocampus, accompanied by the activation of transcription factor NF-κB and the release of proinflammatory factors.

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