Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.

In general, the more hydrophobic conjugates showed a trend for increased placental accumulation compared to the less hydrophobic conjugates, which is likely due to hydrophobicity-driven serum binding profiles. 24 , 30 However, the accumulation of PC-DCA siRNA was significantly higher than DCA and Chol siRNA, despite being the least hydrophobic of the three. 30 This result suggests that a choline moiety on hydrophobic conjugates may further drive placental accumulation.

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