Optimized Administration of the M4 PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in Mecp2+/- Mice.

ACS Chem Neurosci · 2022 · PMC9266622 · PMID 35671352

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failed to reach statistical significanceno p-value reported

While this failed to reach statistical significance, a decrease in the number of breaths equates to a decrease in opportunities for apneas to present.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Optimized Administration of the M<sub>4</sub> PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in <i>Mecp2</i><sup><i>+/</i>-</sup> Mice.

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