miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium.

Accordingly, qPCR evaluation confirmed the up-regulation to be significant with stretch and a strong trend with tachycardia ( Figure 3 B). 2.3. miR-1183 as a Biomarker in Human Cardiac Tissue Considering the novelty of microarray findings, we further investigated whether miR-1183 is also regulated in chronic remodeling and might serve as a tissue biomarker.

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The authors observed high levels of plasma miR-1183 and a positive trend regarding tissue expression in the papillary muscle.

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