Sclerostin in Excessive Drinkers: Relationships with Liver Function and Body Composition.

Creatinine showed a trend to higher values among obese patients vs. overweight and normal individuals (KW = 6.72; p = 0.035), but not when patients with ascites were excluded (KW = 5.83; p = 0.054); moreover, logistic regression analysis showed that the only variable related to obesity was sclerostin ( p = 0.023).

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Although in that study body fat was not assessed, sclerostin did show a significant relationship with histomorphometrically assessed liver fat, although not with Knodell index or liver function, besides a direct, borderline significant relationship with serum bilirubin ( p = 0.046) [ 45 ].

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