Although there was a similar trend as was observed with the plasmin-loaded T cells, when we compared the number of mDCs migrating toward CCL21 in the presence of plasminogen-loaded T cells, the data failed to reach statistical significance on any migration parameter ( Fig. 4 , E – G ).
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Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses.
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