A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo.

Since most mutations were found in the replicase proteins, we indeed found a clear increase in RNA replication kinetics for GLT1-20M and GLT1cc compared to GLT1-mut4B reporter replicons, suggesting that titer enhancement in part might be due to higher RNA replication efficiency ( Fig 6B ), although the differences did not reach statistical significance due to the high standard deviation between replicates.

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