Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits.

Elife · 2022 · PMC9273217 · PMID 35731039

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Although circulating markers of bone formation (P1NP) and osteoclast activation (RANK Ligand) were not altered in BMAd- Pnpla2 -/- mice, markers for bone resorption (CTX-1) and osteoclast activation (TRACP5b) were decreased or showed a strong trend towards reduction, respectively ( Figure 3—figure supplement 2G-J ).

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