Population Pharmacokinetics and Exposure-Safety Relationships of Alisertib in Children and Adolescents With Advanced Malignancies.

J Clin Pharmacol · 2022 · PMC9274904 · PMID 34435684

Europe PMC DOI

hedged sentence

0.3600

closest p · 7.2× alpha

0.3600

boldest claim

The sentences

did not reach statistical significanceP = .36not close (p > 0.1)

The relationship between the incidence of febrile neutropenia and C ss,avg was significant in patients with solid tumors ( P = .01) but did not reach statistical significance ( P = .36) in patients with leukemia.

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