A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells.

A smaller decrease was present in Z-138 cells which did not reach statistical significance (p = 0.05), suggesting there may be other mechanisms contributing to the mitotic dysregulation seen in these cells.

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We found a significant loss in total viable cells in 7 of 8 cells lines relative to DMSO control with a highly significant reduction in 4 cell lines (CCMCL1, Z-138, Jeko, and UPN-1 with < 20% total viable cells with 50 nM TAK-981) and a moderate level of activity in 3 MCL cell lines (SP53, Granta, Mino- < 50% total viable cells with 100 nM of TAK-981) and activated B-cells (Fig. 2 A).

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