Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression.

Both backbone and IL7 coding virus-treated groups showed a trend for the reduction of tumor volumes, however IL7 coding virus-treated animals had notably smaller tumors than mock and Ad5/3-E2F-d24-treated animals ( p < .0001 and p = .0463, respectively) ( Figure 1h ).

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Moreover, we observed a positive trend in immune cell frequency between unarmed virus-treated group and IL7 virus-treated group, although the difference was not significant.

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