Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies.

ANA + NS and UCTD patients also showed a trend to increased proportions of Tfh cells, which was smaller than that seen in SARD, and which appeared to result from small increases in the Th1 and Th17 subsets, together with a significant increase in the Th2 cell subset ( Figure 1D ).

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In contrast, there was only a slight trend to increased Tph17 cells in these non-SARD groups, which was significantly less than that seen in early SARD ( Figure 1F ).

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