Multicenter and prospective trial of anti-epileptics for early seizure prevention in mild traumatic brain injury with a positive computed tomography scan.

performed a systematic literature review and meta-analysis in 2019 of the effectiveness of AEDs for seizure prevention in all TBI subtypes and only identified two retrospective studies that included mild TBI.[ 23 ] Two subsequent retrospective papers have reported increased incidence of early PTS in patients without AEDs that did not reach statistical significance.[ 4 , 13 ] All of these studies had low numbers of mild TBI patients (<500 total) and had overall incidence rates of 0.7–3.2%.[ 4 , 13 ] We completed a multicenter and prospective trial evaluating the effects of prophylactic AEDs in mild TBI to address these shortcomings.

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