Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.

Eur J Clin Pharmacol · 2022 · PMC9283167 · PMID 35648149

Europe PMC DOI

hedged sentence

0.1200

closest p · 2.4× alpha

0.1200

boldest claim

The sentences

did not reach statistical significancep = 0.12not close (p > 0.1)

However, 4βOHC concentrations were lower in patients with obesity expressing CYP3A4 *1/*22 compared with CYP3A4 *1/*1 ( p = 0.024), whereas in the normal to overweight individuals, the difference did not reach statistical significance ( p = 0.12) (Supplementary Fig.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.