IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans.

Consistent with the other results, there was a highly significant increase in F4/80 + CD11b + CD11c + macrophages in both the inguinal and epididymal adipose tissue and all lymphoid tissues studied in Aid −/− vs WT mice after HFD feeding (Fig. 2d and ESM Fig. 4 ).

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Total B cells were also increased in the VAT of Aid −/− mice but the difference did not reach statistical significance compared with WT mice; however, we found that CD1d low B cells in VAT were significantly increased in Aid −/− mice (ESM Fig. 3 ).

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