On the other hand, OA at 100 nM exerted a strong trend toward eEF2 phosphorylation even in the absence of Aβ42, suggesting a role of PP1 in basal eEF2 dephosphorylation independent of Aβ42.
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Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2.
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