All four studies from Europe showed a trend towards a lower risk of breast cancer in patients with pSS ( 7 , 8 , 10 , 15 ).
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Risk, Incidence, and Mortality of Breast Cancer in Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis.
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The multivariate meta-regression analysis of the above subgroups indicated that only the geographical area was at borderline significance ( P interaction =0.078), suggesting that it may be the source of heterogeneity ( Table 2 ).