Untargeted Metabolome- and Transcriptome-Wide Association Study Suggests Causal Genes Modulating Metabolite Concentrations in Urine.

However, none of these candidate genes (14 for the ALMS1 -NAC and 6 for the HPS1 -TMA association pair) produced a pseudospectrum containing even a single nominally significant signal pointing to these metabolites (data not shown).

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The QQ-plot of all pairwise associations ( Figure 1 ) is well calibrated, with four highly significant associations (FDR < 0.05) (involving the ALMS1 and HPS1 genes).

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